Work

Involvement of interleukin-15 and interleukin-21, two γ-chain-related cytokines, in celiac disease

Year: 2009

Type: review

Abstract: Celiac disease (CD), an enteropathy caused by dietary gluten in genetically susceptible individuals, is histologically characterized by villous atrophy, crypt cell hyperplasia, and increased number of intra-epithelial lymphocytes. The nature of CD pathogenesis remains unclear, but recent evidence indicates that both innate and adaptive immune responses are necessary for the phenotypic expression and pathologic changes characteristic of CD. Extensive studies of molecules produced by immune cells in the gut of CD patients have led to identification of two cytokines, namely interleukin (IL)-15 and IL-21, which are thought to play a major role in orchestrating the mucosal inflammatory response in CD. Here we review the current knowledge of the expression and function of IL-15 and IL-21 in CD.

Source: World Journal of Gastroenterology

DOI: 10.3748/wjg.15.4609

Authors: Daniela De Nitto, Ivan Monteleone, Eleonora Franzè, Francesco Pallone, Giovanni Monteleone

Institutions: University of Rome Tor Vergata, University Hospital Heidelberg

Language: English

Topic: Celiac Disease Research and Management

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W1834807331