Work

Author response: Pre-complexation of talin and vinculin without tension is required for efficient nascent adhesion maturation

Year: 2021

Type: peer-review

Abstract: Pre-complexation of vinculin with talin’s R8 domain facilitates nascent adhesion maturation by unfolding talin, increasing vinculin binding, and thereby transmitting traction forces to the environment.

DOI: 10.7554/elife.66151.sa2

Authors: Sangyoon J Han, Evgenia V Azarova, Austin J Whitewood, Alexia Bachir, Edgar Guttierrez, Alex Groisman, Alan R Horwitz, Benjamin T Goult, Kevin M Dean, Gaudenz Danuser

Institutions: Michigan Technological University, The University of Texas Southwestern Medical Center, University of Kent, University of Virginia, University of California San Diego

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

OpenAlex ID: W3142751079

Cites:

Cited by: 1

Related to: 10