High-resolution gene mapping using admixture linkage dis-equilibrium
Year: 2002
Type: article
Abstract: This note reports simulation study on the rate of decay in linkage disequilibrium (LD) in mixed populations over multiple discrete generations and explores the usefulness of the LD analysis in highresolution gene mapping. The results indicate that the smaller the recombination fraction and the fewer generations since admixture event, the higher power of the approach in gene mapping. The expected estimate of recombination fraction would give an estimate that is slightly biased upwards, if relevant genes are in tight linkage. The estimated recombination fraction is usually larger than the true value within 2–5 generations. From generations 10–20, the mean estimates are in good agreement with the true value. The method presented here enables estimation of means and corresponding confidence intervals of the recombination fraction at any number of generations.
Source: Chinese Science Bulletin
DOI: 10.1007/bf03183315
Institutions: Fudan University, Northwest A&F University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2027510988