Oxidative Stress in Neurodegenerative Diseases
Year: 2013
Type: book-chapter
Abstract: As a necessary consequence of the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), aerobic organisms, from man to microbe, have developed an elaborate system of cytoprotection against oxidative stress. Most living organisms have a system of defences, which is both elaborate and redundant, to protect them from the potential damage that can be inflicted by both ROS and RNS. Proteins which are involved in metabolism and signalling are regulated by posttranslational modifications that influence their catalytic activity, rates of turnover and targeting to subcellular locations. A common hallmark of many neurodegenerative diseases and indeed of a number of other diseases such as type 2 diabetes is the presence of proteinaceous deposits in the affected tissues and organs, which, in some cases, are believed to be the main causative agents of the clinical symptoms.
Source: Wiley eBooks
Parent work: Metal‐based Neurodegeneration
Authors: Robert Crichton, Roberta Ward
Institution: UCLouvain
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3143454653