Work

TAT delivery of a PTEN peptide inhibitor has direct cardioprotective effects and improves outcomes in rodent models of cardiac arrest

Year: 2021

Type: article

Abstract: We have designed a cell-permeable peptide, TAT-PTEN9c, to improve cardiac arrest survival. It blocked endogenous PTEN binding to its adaptor and enhanced Akt signaling in mouse cardiomyocytes. It improved mouse survival after cardiac arrest, which is related to improved glucose metabolism and reduced glucose shunting to sorbitol in critical organs.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00513.2020

Authors: Xiangdong Zhu, Jing Li, Huashan Wang, Filip M. Gasior, Chunpei Lee, Shaoxia Lin, Zhiyi Zhu, Youhua Wang, Cody N. Justice, J. Michael O'Donnell, Terry L. Vanden Hoek

Institutions: University of Illinois Chicago, University of Illinois Hospital & Health Sciences System

Language: English

Topic: Cardiac Arrest and Resuscitation

Subfield: Emergency Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Chicago Biomedical Consortium, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences

Awards: G1293817883, G1936385195, Novel Therapies for CPR, G3836447628, G3977087618, G4741629440, G6250773913, G6422044138

OpenAlex ID: W3143786800

FWCI: 1.267

Cites: 34

Cited by: 6

Related to: 10