Year: 2021
Type: article
Abstract: The pressing need of new antimicrobial products is growing stronger, particularly because of widespread antimicrobial resistance, endangering our ability to treat common infections. The recent coronavirus pandemic has dramatically highlighted the necessity of effective antibacterial and antiviral protection. This work explores at the molecular level the mechanism of action of antibacterial nanocapsules assembled in virus-like particles, their stability and their interaction with mammal and antimicrobial model membranes. We use Molecular Dynamics with force-fields of different granularity and protein design strategies to study the stability, self-assembly and membrane poration properties of these nanocapsules.
Source: Nanoscale
DOI: 10.1039/d0nr08146a
Institution: King's College London
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Awards: G116629194, The UK High-End Computing Consortium for Biomolecular Simulation, G233101189, Peta-5: A National Facility for Petascale Data Intensive Computation and Analytics, G2510799378, The UK High-End Computing Consortium for Biomolecular Simulation, G358276009, G3835265546, EPSRC Centre for Doctoral Training in Cross-Disciplinary Approaches to Non-Equilibrium Systems, G6661763476
OpenAlex ID: W3144069503