Work

NRG4-ErbB4 signaling represses proinflammatory macrophage activity

Year: 2021

Type: article

Abstract: Proinflammatory macrophages are essential drivers of colitis and express the growth factor receptor ErbB4. This study tested the role of ErbB4 and its specific ligand, NRG4, in regulating macrophage function. We show that endogenous NRG4-ErbB4 signaling limits macrophage production of proinflammatory cytokines in vitro and limits colitis severity in vivo and thus is a potential target for therapeutic intervention.

Source: American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI: 10.1152/ajpgi.00296.2020

Authors: Michael A. Schumacher, Isabella C. Dennis, Cambrian Y. Liu, Cache Robinson, Judie Shang, Jessica K. Bernard, M. Kay Washington, D. Brent Polk, Mark R. Frey

Institutions: University of Southern California, Children's Hospital of Los Angeles, Saban Research Institute, Vanderbilt University, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center

Language: English

Topic: Inflammatory Bowel Disease

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Crohn's and Colitis Foundation, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Cytokine regulation of intestinal epithelial restitution, G1651600167, G2005906739, G2011606372, Stem Cell Dynamics in Colonic Epithelial Repair, G3925292575, G4183070484

OpenAlex ID: W3144843412

FWCI: 2.638

Cites: 55

Cited by: 40

Related to: 10