Work

The Changes of HIF-1α and VEGF Expression After TACE in Patients With Hepatocellular Carcinoma

Year: 2016

Type: review

Abstract: As a common malignant tumor, hepatocellular carcinoma (HCC) has a high prevalence and is a serious threat to human health. The surgical resection rate of HCC is low, and the prognosis is poor. Although transarterial chemoembolization (TACE) is the main treatment for HCC patients who are not candidates for surgical resection, it is not considered a curative procedure. For HCC, poor TACE efficacy or TACE failure may be related to tumor angiogenesis of the residual disease. Among the many regulatory factors in tumor angiogenesis, hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) play vital roles in this process. In this paper, we conducted a review of the dynamic change and relevance of HIF-1α and VEGF levels after TACE of HCC patients.

Source: Journal of Clinical Medicine Research

DOI: 10.14740/jocmr2496w

Authors: Kang Liu, Xu-Li Min, Juan Peng, Ke Yang, Lin Yang, Xiao-Ming Zhang

Institutions: North Sichuan Medical University, Yan'an University, Affiliated Hospital of North Sichuan Medical College

Language: English

Topic: Hepatocellular Carcinoma Treatment and Prognosis

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Department of Science and Technology of Sichuan Province