Biosynthesis of para-Cyclophane-Containing Hirsutellone Family of Fungal Natural Products
Year: 2021
Type: article
Abstract: Hirsutellones are fungal natural products containing a macrocyclic para- cyclophane connected to a decahydrofluorene ring system. We have elucidated the biosynthetic pathway for pyrrocidine B ( 3 ) and GKK1032 A 2 ( 4 ). Two small hypothetical proteins, an oxidoreductase and a lipocalin-like protein, function cooperatively in the oxidative cyclization of the cyclophane, while an additional hypothetical protein in the pyrrocidine pathway catalyzes the exo- specific cycloaddition to form the cis- fused decahydrofluorene.
DOI: 10.1021/jacs.1c00098
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G4305609567, G5328308195, G863947390
OpenAlex ID: W3145500112