Brain Protection for Aortic Arch Surgery: A Randomized Trial of Axillary Versus Innominate Artery Cannulation – The ACE CardioLink-3 Trial
Year: 2020
Type: dissertation
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Neuroprotection remains the cornerstone of successful aortic surgery however there is no consensus as to the optimal strategy. We compared the safety and efficacy of innominate to axillary artery cannulation for delivering antegrade cerebral protection (ACP) during proximal aortic arch surgery. This randomized study allocated 111 individuals to either innominate or axillary cannulation. The primary safety outcome was the appearance of new severe ischemic lesions on the postoperative compared with the preoperative diffusion-weighted (DW)- MRI. The primary efficacy outcome was the between-groups difference in total operative time. 102 individuals were included in the primary safety analysis. New severe ischemic lesions occurred in 19 participants (38.8%) in the axillary vs. 18 (34%) in the innominate group (p for non-inferiority = 0.0009). Total operative times were comparable (p for superiority = 0.47). Our DW-MRI assessments indicate that ACP with innominate cannulation is safe and affords similar neuroprotection to axillary cannulation during aortic surgery.
Source: TSpace (University of Toronto)
Author: Vinay Garg
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3146261626