Work

Prodrug Systems (II): A Perspective of Polymer-Based Doxorubicin Prodrug Systems towards Chemotherapy

Year: 2021

Type: article

Abstract: Utilizing biocompatible polymers as platforms to covalently conjugate with chemotherapeutics to construct polymer-based prodrugs and their nano drug delivery systems has attracted great attention in recent years.This perspective reviewed state-of-the-arts for polymer-based doxorubicin prodrugs and the related nanodelivery systems, including: (1) pH-responsive polymer-doxorubicin prodrugs/conjugates; (2) pH/redoxdual responsive prodrugs/conjugates; (3) reactive oxygen species/hypoxia-responsive polymer-doxorubicin prodrugs; (4) tumor receptor targeting polymer prodrugs; (5) enzyme-responsive polymer-doxorubicin prodrugs.Finally, possible future perspectives were also stated and discussed.

Source: Medicine Research

DOI: 10.21127/yaoyimr20200023

Authors: Zhao Wang, Zhao Wang, Filipe Olim, Jingjing Sun, Ana Rute Neves, Fátima Mendes, Helena Tomás, and Ruilong Sheng, Filipe Olim, Jingjing Sun, Ana Rute Neves, Fátima Mendes, Helena Tomás, and Ruilong Sheng

Institutions: Jinling Institute of Technology, Centro de Química da Madeira, Universidade da Madeira, University of Pittsburgh

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Agência Regional para o Desenvolvimento da Investigação, Tecnologia e Inovação, Government of Jiangsu Province, Natural Science Foundation of Jiangsu Province, Jinling Institute of Technology, Fundação para a Ciência e a Tecnologia

Awards: G1044059294, G1516346500, G1518577413, Centro de Química da Madeira, G2269067133, G2982190525, G3418550662, G48031964, G6947173766, G7514636649, G7990520395, Centro de Química da Madeira, G8699419952, G969483266

OpenAlex ID: W3147084871

FWCI: 0.131

Cites: 30

Cited by: 2

Related to: 10