Work

Driving T cells to human atherosclerotic plaques: CCL3/CCR5 and CX3CL1/CX3CR1 migration axes

Year: 2021

Type: article

Study design: Observational Study

Abstract: T-cell accumulation in atherosclerotic plaques contributes to plaque destabilization. We found that several chemokine receptors are differentially expressed on peripheral blood compared to plaque-resident T cells and corresponding ligands are upregulated in plaques. These data indicate that T-cell migration into human atherosclerotic plaques may predominantly occur via CCR5-CCL3 and CX3CR1-CX3CL1 interactions.

Source: European Journal of Immunology

DOI: 10.1002/eji.202049004

Authors: Alexey Komissarov, Daria Potashnikova, Michael L. Freeman, Vladimir Gontarenko, Derenik Maytesyan, Michael M. Lederman, Elena Vasilieva, Leonid Margolis

Institutions: Russian University of Medicine, University Hospitals of Cleveland, University Hospitals Cleveland Medical Center, Case Western Reserve University, National Medical Research Center of Surgery named after A. Vishnevsky, City Clinical Hospital No15 named. O. M. Filatova, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Russian Science Foundation, National Institutes of Health, National Institute of Child Health and Human Development

Awards: G3986102385, G9000039438

OpenAlex ID: W3148471423

FWCI: 1.956

Cites: 9

Cited by: 29

Related to: 10