Year: 2020
Type: dissertation
Abstract: Neurogenesis, the generation of new neurons in the hippocampus, has been identified as an underlying mechanism for forgetting of hippocampus-dependent memories in adult and infant mice. However, a recent study failed to replicate neurogenesis-mediated forgetting in rats using multiple measures of spatial memory in the Morris water maze paradigm. Thus, the current study aims to explore explanations for this discrepancy by investigating neurogenesis-mediated forgetting in mice using the Morris water maze paradigm. I analyzed behavioral changes associated with increased neurogenesis in the Morris water maze with multiple quantitative measures in both adult and infant mice. My results showed that neurogenesis-mediated forgetting is reflected in behavioral measures that capture the loss of memory precision, but not measures that only capture the memory gist. I also found evidence that neurogenesis-associated loss of memory precision results in memory generalization.
Source: TSpace (University of Toronto)
Author: Chunan Duan
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3148926050