Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Year: 2011
Type: article
Study design: Observational Study
Source: Nature Genetics
DOI: 10.1038/ng.970
Authors: John C Chambers, Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study, Weihua Zhang, Joban Sehmi, Xinzhong Li, Mark N Wass, Pim Van der Harst, Hilma Holm, Serena Sanna, Maryam Kavousi, Sebastian E Baumeister, Lachlan J Coin, Guohong Deng, Christian Gieger, Nancy L Heard-Costa, Jouke-Jan Hottenga, Brigitte Kühnel, Vinod Kumar, Vasiliki Lagou, Liming Liang, Jian'an Luan, Pedro Marques Vidal, Irene Mateo Leach, Paul F O'Reilly, John F Peden, Nilufer Rahmioglu, Pasi Soininen, Elizabeth K Speliotes, Xin Yuan, Gudmar Thorleifsson, Behrooz Z Alizadeh, Larry D Atwood, Ingrid B Borecki, Morris J Brown, Pimphen Charoen, Francesco Cucca, Debashish Das, Eco J C de Geus, Anna L Dixon, Angela Döring, Georg Ehret, Gudmundur I Eyjolfsson, Martin Farrall, Nita G Forouhi, Nele Friedrich, Wolfram Goessling, Daniel F Gudbjartsson, Tamara B Harris, Anna-Liisa Hartikainen, Simon Heath, Gideon M Hirschfield, Albert Hofman, Georg Homuth, Elina Hyppönen, Harry L A Janssen, Toby Johnson, Antti J Kangas, Ido P Kema, Jens P Kühn, Sandra Lai, Mark Lathrop, Markus M Lerch, Yun Li, T Jake Liang, Jing-Ping Lin, Ruth J F Loos, Nicholas G Martin, Miriam F Moffatt, Grant W Montgomery, Patricia B Munroe, Kiran Musunuru, Yusuke Nakamura, Christopher J O'Donnell, Isleifur Olafsson, Brenda W Penninx, Anneli Pouta, Bram P Prins, Inga Prokopenko, Ralf Puls, Aimo Ruokonen, Markku J Savolainen, David Schlessinger, Jeoffrey N L Schouten, Udo Seedorf, Srijita Sen-Chowdhry, Katherine A Siminovitch, Johannes H Smit, Timothy D Spector, Wenting Tan, Tanya M Teslovich, Taru Tukiainen, Andre G Uitterlinden, Melanie M Van der Klauw, Ramachandran S Vasan, Chris Wallace, Henri Wallaschofski, H-Erich Wichmann, Gonneke Willemsen, Peter Würtz, Chun Xu, Laura M Yerges-Armstrong, Goncalo R Abecasis, Kourosh R Ahmadi, Dorret I Boomsma, Mark Caulfield, William O Cookson, Cornelia M van Duijn, Philippe Froguel, Koichi Matsuda, Mark I McCarthy, Christa Meisinger, Vincent Mooser, Kirsi H Pietiläinen, Gunter Schumann, Harold Snieder, Michael J E Sternberg, Ronald P Stolk, Howard C Thomas, Unnur Thorsteinsdottir, Manuela Uda, Gérard Waeber, Nicholas J Wareham, Dawn M Waterworth, Hugh Watkins, John B Whitfield, Jacqueline C M Witteman, Bruce H R Wolffenbuttel, Caroline S Fox, Mika Ala-Korpela, Kari Stefansson, Peter Vollenweider, Henry Völzke, Eric E Schadt, James Scott, Marjo-Riitta Järvelin, Paul Elliott, Jaspal S Kooner
Institutions: National Health Service, Imperial College Healthcare NHS Trust, Ealing Hospital NHS Trust, Imperial College London, Hammersmith Hospital, Royal Brompton Hospital, University Medical Center Groningen, University of Groningen, deCODE Genetics (Iceland), Institute of Genetic and Biomedical Research, National Research Council, Erasmus MC, Netherlands Consortium for Healthy Ageing, Universität Greifswald, Army Medical University, Southwest Hospital, Helmholtz Munich, Boston University, Vrije Universiteit Amsterdam, Institute of Medical Science, The University of Tokyo, The University of Tokyo, Centre for Human Genetics, Churchill Hospital, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Harvard University, Addenbrooke's Hospital, MRC Epidemiology Unit, Medical Research Council, Centre Hospitalier Universitaire Vaudois, Institute of Social and Preventive Medicine, University of Lausanne, University of Eastern Finland, University of Oulu, University of Michigan, GlaxoSmithKline (United States), Michigan Medicine, Washington University in St. Louis, University of Cambridge, Mahidol University, Amsterdam Neuroscience, Johns Hopkins University, Johns Hopkins Medicine, University Hospital of Geneva, John Radcliffe Hospital, Universitätsmedizin Greifswald, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Dana-Farber Brigham Cancer Center, National Institutes of Health, National Institute on Aging, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, University of Toronto, Toronto Western Hospital, University of Birmingham, Queen Mary University of London, William Harvey Research Institute, Fondation Jean Dausset-CEPH, University of North Carolina at Chapel Hill, National Institute of Diabetes and Digestive and Kidney Diseases, National Heart, Lung, and Blood Institute, QIMR Berghofer Medical Research Institute, Massachusetts General Hospital, Framingham Heart Study, National University Hospital of Iceland, Leiden University Medical Center, Amsterdam Public Health, Finnish Institute for Health and Welfare, University of Münster, Mount Sinai Hospital, Lunenfeld-Tanenbaum Research Institute, King's College London, Lifelines, München Klinik, Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität München, University of Maryland, Baltimore, National Institute for Health and Care Research, University of Helsinki, Helsinki University Hospital, Institute for Molecular Medicine Finland, University of Iceland, Icahn School of Medicine at Mount Sinai
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Funders: National Science Foundation, AstraZeneca, GlaxoSmithKline, School of Medicine, Boston University, Torsten Söderbergs Stiftelse, Yrjö Jahnssonin Säätiö, Wellcome Trust, Cancer Research UK, National Institute for Health and Care Research, British Heart Foundation, Imperial College London, Imperial College Healthcare NHS Trust, European Commission, European Science Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Rijksuniversiteit Groningen, Bundesministerium für Bildung und Forschung, Nierstichting, Erasmus Medisch Centrum, Diabetes Fonds, Biomedicum Helsinki-säätiö, Hjärt-Lungfonden, Karolinska Institutet, Knut och Alice Wallenbergs Stiftelse, Novo Nordisk, Stockholms Läns Landsting, Vetenskapsrådet, Universitair Medisch Centrum Groningen, Oulun Yliopisto, Instrumentariumin Tiedesäätiö, Novo Nordisk Fonden, National Institutes of Health, Directorate for Biological Sciences, Medical Research Council, Japan Society for the Promotion of Science, Jenny ja Antti Wihurin Rahasto, Helmholtz Zentrum München, Biocenter, University of Oulu, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: G2225345073, CD40-Induced TCR Revision: A Mechanism for Autoimmunity, Evaluation of MICA variations and serum MICA as prognostic factors for Chronic hepatitis C patients, GENE-ENVIRONMENT INTERPLAY IN ALCOHOLISM, Aging-related Traits and Disease Risk Factors in a Sardinian Population Cohort, The complexity behind Mendelian disease: investigation into genetic and environmental influences in arrhythmogenic cardiomyopathy, G3860752689, G4411580604, G5145334339, Vitamin D and the risk of cardiovascular disease and related traits: a large-scale genetic association study, G5897142711, G6969890512, Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics., G731175165, Belfast Early detection and determinants of stroke, coronary heart disease and congestive heart failure: the Caerphilly Prospective Study. Phase 5 follow-up, RENEWAL: Psychosocial and biological factors in the occurrence of cardiovascular disease: the Whitehall II study, Nonalcoholic Steatohepatitis: Natural History and Therapy, Nonalcoholic Steatohepatitis: Natural History, Pathogenesis and Therapy
OpenAlex ID: W2143286837