Work

Carvacrol suppresses the expression of inflammatory marker genes in D-galactosamine-hepatotoxic rats

Year: 2013

Type: article

Abstract: OBJECTIVE: To unravel the mechanism of anti-inflammatory activity of carvacrol in D-galactosamine (D-GalN)-induced hepatotoxic rats. METHODS: The mRNA and protein expression levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and nuclear factor kappa-B (NF-κB) were assayed by semi-quantitative reverse transcriptase polymerase chain reaction (RTPCR) and western blot analysis. RESULTS: We found that the mRNA and protein expressions of TNF-α, IL-6, iNOS, COX-2 and NF-κB were significantly up-regulated in D-galactosamine induced hepatotoxic rats and treatment with carvacrol significantly down-regulated the expressions of these genes showing the mechanism behind the anti-inflammatory activity of carvacrol. CONCLUSIONS: All above results reveal that the carvacrol well known anti-inflammatory activities in D-galactosamine induced hepatotoxic rats.

Source: Asian Pacific Journal of Tropical Medicine

DOI: 10.1016/s1995-7645(13)60024-3

Authors: Balakrishnan Aristatile, Abdullah H Al-Assaf, Kodukkur Viswanathan Pugalendi

Institutions: Bharathiar University, King Saud University, Annamalai University

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2080558596

FWCI: 2.823

Cites: 49

Cited by: 61

Related to: 10