Work

Body Clock: Matching Personalized Multimorbidity and Fast Aging Using Information Entropy

Year: 2021

Type: preprint

Abstract: With aging, most older adults are at risk of having more than two diseases, conventionally defined as multimorbidity. We determined body organ disease number (BODN) as a new multimorbidity index. We measured the degree to which each disease level, from mild to severe, predicts longitudinal BODN uncoupled from chronological age. We determined Body Clock using global disease levels burden from all systems predicting longitudinal BODN for each individual, which is a proxy of the personalized rate of biological aging. Change in Body Clock predicts late-life age-related outcomes and can be used for geriatric clinics and clinical trials for precision medicine.

Source: medRxiv

DOI: 10.1101/2021.03.29.21254372

Authors: Shabnam Salimi, Aki Vehtari, Marcel Salive, Luigi Ferrucci

Institutions: University of Maryland, Baltimore, Aalto University, National Institutes of Health, National Institute on Aging

Language: English

Topic: Chronic Disease Management Strategies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Institute on Aging