Interleukin-6 polymorphisms modify the risk of periodontitis:a systematic review and meta-analysis
Year: 2009
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: OBJECTIVE: To clarify the association of IL-6 polymorphisms and periodontitis, a meta-analysis of case-control studies and a systemic review were conducted. MATERIAL AND METHODS: We performed a literature search using PubMed and Medline database to May 2009, with no restrictions. We also reviewed references from all retrieved articles. Six case-control studies involving 1 093 periodontitis cases and 574 controls were selected for meta-analysis to assess the purported associations between IL-6 polymorphisms and the risk of periodontitis. IL-6 -174 G/C and -572 C/G polymorphisms were included in the present meta-analysis, and the association between IL-6 -6331 T/C polymorphism and the risk of periodontitis was adequately reviewed as well. RESULTS AND CONCLUSION: The present meta-analysis indicates that the IL-6 -174 G allele could not modify the risk of chronic periodontitis, but increased the risk of aggressive periodontitis. And -572 C/G polymorphism is associated with the pathogenesis of periodontitis, including chronic periodontitis or aggressive periodontitis.
Authors: Mei-ying Shao, Ping Huang, Ran Cheng, Tao Hu
Institutions: Sichuan University, State Key Laboratory of Oral Diseases
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2037522393