Work

Inflammasome-independent functions of AIM2

Year: 2021

Type: article

Abstract: AIM2 is widely known for its role as a cytosolic dsDNA receptor that activates the inflammasome. In this issue of JEM, Ma et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201796) describe an inflammasome-independent function of AIM2 in microglia that restrains neuroinflammation via a novel crosstalk between AIM2 and cGAS signaling.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20210273

Authors: Junjie Zhao, William Miller-Little, Xiaoxia Li

Institutions: Cleveland Clinic, Cleveland Clinic Research, Case Western Reserve University

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute of General Medical Sciences