Fatty Acid Sensing in the Dorsal Vagal Complex and Regulation of Triglyceride-rich very Low-density Lipoprotein Secretion
Year: 2016
Type: dissertation
Abstract: Fatty acid sensing in the hypothalamus lowers hepatic glucose production and secretion of triglyceride-rich very low-density lipoproteins (VLDL-TG). However, whether other brain regions can sense fatty acids to regulate hepatic nutrient metabolism is unknown. Here, we demonstrated that oleic acid infusion into the dorsal vagal complex (DVC) lowers the rate of VLDL-TG secretion in rats. Given that long-chain acyl-CoA synthetase (ACSL)-mediated esterification of long-chain fatty acids (LCFAs) to LCFA-CoA is necessary for hypothalamic fatty acid sensing to lower glucose production, we next examined the role of ACSL in DVC fatty acid sensing. We found that all five ACSL members (ACSL1, 3-6) are expressed in the DVC at the protein level. Chemical inhibition of ACSL in the DVC prevented a DVC infusion of oleic acid from lowering VLDL-TG secretion. These data introduce the DVC as a novel site of fatty acid sensing in the regulation of hepatic VLDL-TG secretion.
Source: TSpace (University of Toronto)
Author: Beini Wang
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3152371720