Work

Association of Radiotherapy-Related Intestinal Injury and Cancer-related Fatigue: A Brief Review and Commentary.

Year: 2021

Type: review

Abstract: Radiotherapy treatment-induced intestinal injury and gut microbial perturbation/dysbiosis have been implicated in the pathobiology of cancer-related fatigue. The objective of this brief review was to explore the available evidence of the relationship between intestinal injury and self-reported fatigue, especially among cancer patients. The scientific evidence-including our own-linking gut mucosal barrier dysfunction and gut microbial perturbation/dysbiosis induced by cancer treatment with worsening of cancer related fatigue (perhaps through the gut-brain axis) is limited but promising. Emerging data suggest that lifestyle interventions and the administration of specific probiotics may favorably modulate the gut microbiota and potentially mediate beneficial effects leading to improvements in fatigue.

Source: PubMed

Authors: Velda J Gonzalez-Mercado, Sara Marrero, Josué Pérez-Santiago, Maribel Tirado-Gómez, Miguel A Marrero-Falcón, Elsa Pedro, Leorey N Saligan

Institutions: New York University, University of South Florida, University of Puerto Rico, Medical Sciences Campus, University of Puerto Rico System, National Institutes of Health, National Institute of Nursing Research

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Nursing Research, National Institute of General Medical Sciences, National Institute on Minority Health and Health Disparities

Awards: Fatigue and the Gut Microbiome of Patients Receiving Chemoradiotherapy for Rectal Cancer, UPR/MDACC: Partnership for Excellence in Cancer Research (1 of 2), UPR/MDACC: Partnership for Excellence in Cancer Research (2 of 2), Hispanic Alliance for Clinical and Translational Research (Alliance), Puerto Rico Clinical and Translational Research Consortium (PRCTRC)

OpenAlex ID: W3153009162

FWCI: 0.102

Cites: 53

Cited by: 6

Related to: 10