Year: 2021
Type: article
Abstract: Objective: An important criterion that radiopaque poly-3-hydroxy butyrate (PHB) derivatives synthesized and characterized by our study group do not interact with DNA and bovine albumin to be developed as an intravenous contrast agent for radiological imaging.Methods: Interactions of radiopaque PHB derivatives between bovine serum albumin (BSA) and deoxyribonucleic acid (pUC19 DNA and polymerase chain reaction product) were investigated using absorption spectroscopy and agarose gel electrophoresis techniques.Results: Absorption spectroscopy results showed that the radiopaque PHB derivatives did not show any interaction with BSA.Doublestranded annular DNA showed that the interaction between the double-stranded forms of linear DNA did not cause any damage.Conclusion: It was determined that it did not interact with both BSA and various DNA forms.
Source: Bezmialem Science
Author: Arzu EROL
Institution: Zonguldak Bülent Ecevit University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W3153010047