Work

Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers

Year: 2021

Type: review

Abstract: The complex nature of folliculogenesis regulation accounts for its susceptibility to maternal physiological fitness. In obese mothers, progressive expansion of adipose tissue culminates with severe hyperestrogenism and hyperleptinemia with detrimental effects for ovarian performance. Indeed, maternal obesity is associated with the establishment of ovarian leptin resistance. This review summarizes current knowledge on potential effects of impaired leptin signaling throughout folliculogenesis and oocyte developmental competence in mice and women.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms22084270

Authors: Karolina Wołodko, Juan Castillo-Fernandez, Gavin Kelsey, António Galvão

Institutions: InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Babraham Institute, University of Cambridge

Language: English

Topic: Reproductive Biology and Fertility

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,160