An assessment of potential biomarkers of environment enteropathy and its association with age and microbial infections among children in Bangladesh
Year: 2021
Type: article
Study design: Observational Study
Abstract: Interventional studies targeting environment enteropathy (EE) are impeded by the lack of appropriate, validated, non-invasive biomarkers of EE. Thus, we aimed to validate the association of potential biomarkers for EE with enteric infections and nutritional status in a longitudinal birth cohort study. We measured endotoxin core antibody (EndoCab) and soluble CD14 (sCD14) in serum, and myeloperoxidase (MPO) in feces using commercially available enzyme-linked immunosorbent assay (ELISA) kits. We found that levels of serum EndoCab and sCD14 increase with the cumulative incidence of enteric infections. We observed a significant correlation between the fecal MPO level in the children at 24 months of age with the total number of bacterial and viral infections, the total number of parasitic infections, and the total number of diarrheal episodes and diarrheal duration. We observed that the levels of serum EndoCab, sCD14, and fecal MPO at 3 months of age were significantly associated with whether children were malnourished at 18 months of age or not. Biomarkers such as fecal MPO, serum EndoCab and sCD14 in children at an early age may be useful as a measure of cumulative burden of preceding enteric infections, which are predictive of subsequent malnutrition status and may be useful non-invasive biomarkers for EE.
Source: PLoS ONE
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,749
Awards: Protecutive immunity to human cholera in Bangladesh, G1510978416, G1671890814, G1873111418, O-Specific Polysaccharide Responses and Cholera, G3472663962, G3769145211, G516757433, G5551172042, G6010259269, Mucosal immune response to oral cholera vaccine Peru 15, Innate and early B cell responses to V. cholerae, G647409134, G7878150564, Mucosal associated invariant T (MAIT) cells in Vibrio cholerae infection and vaccination, Immune Responses to Vibrio Cholerae in Children, Humoral and adaptive immune responses study in Vibrio cholerae infection, G9000044515, O-Specific Polysaccharide Responses and Cholera, International research training program in vaccine development and public health, G999781830
OpenAlex ID: W3153195500