Potencial Terapêutico Dos Probióticos Na Acne: Uma Revisão Sistemática
Year: 2020
Type: article
Study design: Systematic Review
Abstract: It is estimated that 85% of the population between 12 and 25 years of age has acne at some point in their lives, as it is a very common benign dermatosis. New processes are constantly proposed in order to control this pathology, given the high impact on the companions' quality of life. Within this context, probiotics appear as a therapeutic option, due to their beneficial effects on intestinal health, their ability to fight pathogenic bacteria, assist the skin's barrier function and contribute to the regulation of innate and adaptive immune responses. In this study a systematic review was carried out on the use of probiotics and oral in the treatment of acne through a search in the databases PubMed, Science Direct, SciELO and Google Scholar, in the last 10 years. Clinical trials that evaluate the effectiveness of probiotics in the treatment of acne were selected. A limited number have examined the effects of probiotics on the skin microbiota in acne, but all of them have shown that probiotics modulate the pathophysiological factors of acne, also improving patient compliance with conventional treatment. They can inhibit Cutibacterium acnes by producing similar substances like bacteriocins, inhibit pro-inflammatory cytokines (IL-8) in keratinocytes and increase levels of anti-inflammatory cytokines (IL-10). When applied topically, probiotics improved the skin's protective barrier, increased production of ceramides and also the production of antimicrobial peptides. In view of the great generation that is increasing among probiotics, the clinical data found are still insufficient to demonstrate on a large scale. However, all studies demonstrated significant improvements, demonstrating the great potential of probiotics in the treatment of acne.
Institution: Centro Universitário de Minas Gerais - UniMG
Language: Portuguese
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3153230031