Work

Role of myeloid-derived suppressor cells in hormone-dependent cancers

Year: 2021

Type: article

Abstract: Tumour-infiltrating myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid cells. The main feature of MDSCs is their ability to suppress T-cell activation and function, which leads to immunosuppressive activity in the tumour microenvironment. Higher numbers of circulating and tumour-infiltrating MDSCs have been observed in a large number of patients with various types of tumour, and are linked to poor prognosis, especially in hormone-driven tumours. Recently, it has been demonstrated that the recruitment of MDSCs in prostate cancer confers resistance to canonical endocrine therapies, opening a new approach to the treatment of hormone-driven cancer patients.

Source: Swiss Medical Weekly

DOI: 10.4414/smw.2021.20483

Authors: Siddhartha Mukherjee, Angela R. Elia, Arianna Calcinotto

Institutions: Institute of Oncology Research, Istituto Oncologico della Svizzera Italiana, Università della Svizzera italiana

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W3153430754

FWCI: 0.093

Cites:

Cited by: 2

Related to: 10