Year: 2021
Type: review
Abstract: The enzyme glutamine synthetase (GS), also referred to as glutamate ammonia ligase, is abundant in astrocytes and catalyzes the conversion of ammonia and glutamate to glutamine. Deficiency or dysfunction of astrocytic GS in discrete brain regions have been associated with several types of epilepsy, including medically-intractable mesial temporal lobe epilepsy (MTLE), neocortical epilepsies, and glioblastoma-associated epilepsy. Moreover, experimental inhibition or deletion of GS in the entorhinal-hippocampal territory of laboratory animals causes an MTLE-like syndrome characterized by spontaneous, recurrent hippocampal-onset seizures, loss of hippocampal neurons, and in some cases comorbid depressive-like features. The goal of this review is to summarize and discuss the possible roles of astroglial GS in the pathogenesis of epilepsy.
Source: Frontiers in Neurology
Institutions: Mayo Clinic, Mayo Clinic in Florida, Yale University
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Awards: Metabolomic predictors of circadian vulnerabilities in epilepsy, Dysregulation of Glutamine Synthetase in Human Temporal Lobe Epilepsy, Network analysis for epilepsy surgery, Glutamine Synthetase and the Mechanism of Seizures in Mesial Temporal Lobe Epilep, Yale University Clinical and Translational Science Award Program
OpenAlex ID: W3153759411