Year: 2020
Type: dissertation
Study design: Observational Study
Abstract: Cancer can negatively impact the mental well-being of adolescent and young adult (AYA)-onset cancer survivors; their long-term risk of adverse mental health outcomes is not well-characterized. We used population-based clinical and health administrative databases to determine this risk and associated predictors. We identified 2,208 survivors and 10,457 age, sex, FSA-matched population controls without cancer. Compared to controls, survivors experienced an elevated rate of outpatient psychiatry-related visits (adjusted rate ratio (RR) 1.30; p=0.004) and increased risk of severe psychiatric events (adjusted hazard ratio 1.22; p=0.005). Survivors were also at a higher risk of experiencing schizophrenia-related severe psychiatric events, compared to controls. In models restricted to only survivors, those at highest risk of outpatient visits and severe psychiatric episodes could be identified using demographic and/or treatment characteristics. Survivors initially treated for their cancer in an adult versus a pediatric hospital, had a strikingly higher outpatient visit rate (RR 1.79; p=0.03).
Source: TSpace (University of Toronto)
Author: Riddhita De
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3153800054