Characterizing the Longitudinal Course of Depression after Moderate-Severe Traumatic Brain Injury: Trajectory Analysis at 2, 5, 12 30+ Months Post-TBI
Year: 2019
Type: dissertation
Study design: Observational Study
Abstract: Depression can compound the already devastating effects of moderate-severe traumatic brain injury (TBI). Depression after TBI has been correlated with decreased quality of life, poorer community re-integration, and lowered rates of return to productivity. While the persistence and impact of depressive symptoms have been well-documented in patients with moderate-severe TBI, less is known about the course of depression from the sub-acute to chronic stages of injury. The aim of this thesis was to investigate the trajectories of depressive symptoms from the sub-acute to the chronic stages of moderate to severe TBI and factors that may play a role in the onset and persistence of depression post-injury. Trajectory analysis revealed 4 distinct trajectory classes of depressive symptoms post-injury and multinomial logistic regression did not identify any significant predictive demographic or medical factors of class membership. Establishing factors underlying trajectory membership can help to target patients for early prophylactic treatment.
Source: TSpace (University of Toronto)
Author: Pavel Tselichtchev
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3153975177