Identification of Druggable Host Targets Needed for SARS-CoV-2 Infection by Combined Pharmacological Evaluation and Cellular Network Directed Prioritization Both in vitro and in vivo
Year: 2022
Type: preprint
Source: SSRN Electronic Journal
DOI: 10.2139/ssrn.4038525
Authors: J.J. Patten, Patrick T. Keiser, Deisy Gysi, Giulia Menichetti, Hiroyuki Mori, Callie J. Donahue, Xiao Gan, Italo do Valle, Kathleen Geoghegan-Barek, Manu Anantpadma, RuthMabel Boytz, Jacob L. Berrigan, Sarah Hulsey-Stubbs, Tess Ayazika, Colin O’Leary, Sallieu Jalloh, Florence Wagner, Seyoum Ayehunie, Stephen J. Elledge, Deborah Anderson, Joseph Loscalzo, Marinka Zitnik, Suryaram Gummuluru, Mark N. Namchuk, Albert-László Barabási, Robert A. Davey
Institutions: Boston University, Brigham and Women's Hospital, Northeastern University, Harvard University, National Institutes of Health, Albert Einstein College of Medicine, Howard Hughes Medical Institute, Broad Institute, MatTek Corporation (United States), Central European University - Budapest Campus
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Science Foundation, American Heart Association, Broad Institute, Massachusetts Consortium on Pathogen Readiness, National Institutes of Health, Harvard Data Science Initiative, Harvard University, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases
Awards: G1015653809, G1151355682, G1522214142, Mechanism of cell-associated HIV-1 transmission, G3277991280, G3429738429, Systems Biology of Airway Disease, Antiviral Lead Identification to Treat Filovirus Infections, G4924499859, RAPID:Collaborative Research: Computational Drug Repurposing for COVID-19, Boston Biomedical Innovation Center, G6077599156, G6534348159, Center for Integrated Approached to Undiagnosed Diseases, The Phathophenotype Landscape of Complex Disease, G7971770453, Workshop on Drug Repurposing for Future Pandemics, Small Molecule Inhibitors of Ebola Virus Polymerase Function, Molecular Mechanisms of Filoviral-host Interactions, National Emerging Infectious Diseases Laboratories Operations
OpenAlex ID: W3154117841