Association between air pollution and incidence of dementia: A systematic review and meta-analysis of cohort studies
Year: 2021
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Objective. To estimate the risk of dementia in association with exposure to air pollutants.\nMethods. Six databases were searched. Cohort studies that reported the hazard ratio (HR) of dementia in association with exposure to air pollutants in adults > 40y were included. For all meta-analyses, the random-effects model was used.\nResults. A total of 16 and 13 studies were included in the systematic review and the meta-analysis, respectively. Risk of dementia increased by 4% per 1μg/m3 increase in fine particulate matter level (HR, 1.04; 95%CI, [1.02, 1.06]), which was statistically significant. The risk of dementia increased by 3% per 10μg/m3 increase in nitrogen oxides level (HR, 1.03; 95%CI, [0.98, 1.08]), and by 3% per 10μg/m3 increase in nitrogen dioxide level (HR, 1.03; 95%CI, [1.00, 1.07]); however, the associations were not statistically significant\nConclusion. This meta-analysis indicates a significant association between exposure to fine particulate matter and incidence of dementia.
Author: Ehsan Abolhasani
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W3154233894