Year: 2001
Type: dissertation
Abstract: Sleep exerts important modulating influences on breathing such that a decline in lung ventilation in sleep predisposes individuals to respiratory impairment. Recent data from awake humans also suggest that the circadian system influences breathing. This circadian influence may be potentially important because a decline in ventilation due to circadian effects may exacerbate the decline due to sleep, although this has not been tested. Therefore, by measuring sleep-wake states (using electroencephalography and electromyography), lung ventilation (using barometric plethysmography) and metabolic CO2 production across 24 hour periods in six freely behaving rats, the present study tested and confirmed the hypotheses that: (1) there are circadian rhythms in lung ventilation in wakefulness, non rapid eye movement (NREM) sleep and REM sleep (all p < 0.001), and (2) the magnitude of the change in ventilation from wakefulness to NREM sleep is the same across time of day (p = 0.58).
Author: Kiong Sen Liao
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3154448754