Year: 2021
Type: article
Abstract: Extracellular vesicles (EVs) serve as drug delivery platforms that are, in some cases, superior to synthetic nanoparticles.1 EVs comprise lipid bilayer-enclosed cytoplasmic content and naturally include membrane-associated proteins, several of which have been used for engineering and cargo loading. Since some of these proteins are limited by meager cellular expression and low EV density, Dooley et al.2 (in this issue of Molecular Therapy) at Codiak BioSciences rigorously sought membrane-associated proteins that are highly expressed and enriched in EVs and thus well suited for novel applications in EV engineering.
Source: Molecular Therapy
Author: Kenneth W. Witwer
Institutions: Johns Hopkins University, Johns Hopkins Medicine
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,900
Awards: Novel Separation Methods for exRNA Carriers: Extracellular Vesicles, Lipoprotein Particles, and Protein Aggregates, Extracellular Vesicle and Extracellular RNA Biomarkers of HIV-1 Central Nervous System Pathogenesis and Cigarette Use, Novel Approaches to Capture, Sorting, and Characterization of CNS-Origin Extracellular Vesicles
OpenAlex ID: W3154504529