Year: 2019
Type: dissertation
Study design: Observational Study
Abstract: Numerous adult bipolar disorder (BD) studies have examined cerebral blood flow (CBF) in relation to mood, whereas little is known on this topic in adolescents. We enrolled 129 adolescents (mean age 17.34+/-1.42 years), including 72 BD (28 hypomanic/mixed, 19 depressed, 25 euthymic) and 57 healthy controls (HC). Pseudocontinuous arterial spin labeling (ASL) magnetic resonance imaging (MRI) evaluated CBF, using both a region of interest and whole brain voxel-wise approach. Within-BD analysis examined the association of mania and depression severity with CBF. We found differences in terms of CBF between groups with higher CBF in the BD euthymic group than in HC and symptomatic BD in temporal, precentral, and occipital regions. Severity of depressive symptoms in BD was negatively correlated with CBF in the anterior cingulate cortex and temporal regions. Higher CBF in euthymic BD adolescents may reflect developmentally-specific compensatory CBF regulation mechanisms required to maintain euthymia.
Source: TSpace (University of Toronto)
Author: Toma, Simina
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3154573218