Engineering Cardiovascular Tissue Chips for Disease Modeling and Drug Screening Applications
Year: 2021
Type: review
Abstract: In recent years, the cost of drug discovery and development have been progressively increasing, but the number of drugs approved for treatment of cardiovascular diseases (CVDs) has been limited. Current in vitro models for drug development do not sufficiently ensure safety and efficacy, owing to their lack of physiological relevance. On the other hand, preclinical animal models are extremely costly and present problems of inaccuracy due to species differences. To address these limitations, tissue chips offer the opportunity to emulate physiological and pathological tissue processes in a biomimetic in vitro platform. Tissue chips enable in vitro modeling of CVDs to give mechanistic insights, and they can also be a powerful approach for drug screening applications. Here, we review recent advances in CVD modeling using tissue chips and their applications in drug screening.
Authors: Alex H. P. Chan, Ngan F. Huang
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,950
Funders: U.S. Department of Veterans Affairs, American Heart Association, Tobacco-Related Disease Research Program, National Institutes of Health, U.S. Food and Drug Administration, University of California, San Francisco, Center of Excellence in Regulatory Science and Innovation, National Heart, Lung, and Blood Institute
Awards: iPSC-Derived Smooth Muscle Progenitors in Elastin Hydrogels for Treating Abdominal Aortic Aneurysm, G1533673325, G1814800902, Aligned Nanofibrillar Scaffolds Enhance Angiogenesis and Viability in Ischemia, Substrate Stiffness Modulates Endothelial-to-Mesenchymal Transition, G3522924162, G3531976141, Engineered matrix microarrays to enhance the regenerative potential of iPSC-derived endothelial cells, G3897007235, G5160892468, G5370715225, G5696366343, G5792377579, G5899376848, G794180464, G948357345
OpenAlex ID: W3154621290