Examining Brain and Body Correlates of Cerebrovascular Reactivity Among Adolescents with and without Bipolar Disorder
Year: 2017
Type: dissertation
Study design: Observational Study
Abstract: Cardiovascular disease (CVD) is excessive and premature among individuals with bipolar disorder (BD). Cerebrovascular reactivity (CVR), a marker of cerebrovascular health, is the capacity of the brainâ s blood vessels to vasodilate when induced by vasoactive substances. We examined this topic for the first time in BD. CVR was measured in 25 adolescents with BD and 25 age and sex-matched psychiatrically healthy controls (HCs). Whole-brain analyses showed that BDs have lower CVR in the posterior cingulate gyrus and periventricular white matter. When controlling for differences in body mass index (BMI), additional between group CVR differences were observed in the temporal poles, supramarginal gyrus and lingual gyrus. There were no significant clusters of the brain that were BD>HC. Our results suggest that CVR may be a proxy for future risk of CVD and/or cerebrovascular disease, given the location of anomalous CVR within regions where cerebrovascular pathology occurs in mid-life.
Source: TSpace (University of Toronto)
Author: Adam L. Urback
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3154756630