Work

Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance

Year: 2021

Type: article

Abstract: Recent developments of organoids engineering and organ-on-a-chip microfluidic technologies have enabled the recapitulation of the major functions and architectures of microscale human tissue, including tumor pathophysiology. Nevertheless, there remain challenges in recapitulating the complexity and heterogeneity of tumor microenvironment. The integration of these engineering technologies suggests a potential strategy to overcome the limitations in reconstituting the perfusable microvascular system of large-scale tumors conserving their key functional features. Here, we review the recent progress of in vitro tumor-on-a-chip microfluidic technologies, focusing on the reconstruction of microvascularized organoid models to suggest a better platform for personalized cancer medicine.

Source: Nano Convergence

DOI: 10.1186/s40580-021-00261-y

Authors: Jungeun Lim, Hanna Ching, Jeong-Kee Yoon, Noo Li Jeon, YongTae Kim

Institutions: Georgia Institute of Technology, Seoul National University, The Wallace H. Coulter Department of Biomedical Engineering

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: