Sleep spindles and auditory sensory gating: two measures of cerebral inhibition in preschool-aged children are strongly correlated
Year: 2017
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Sleep spindles and P50 sensory gating are both reflective of cerebral inhibition, however, are differentially active during different phases of sleep. Assessing whether sleep spindles and P50 sensory gating correlate is a first step to evaluate whether these 2 forms of cerebral inhibition reflect overlapping neural circuits. METHODS: EEG data were collected between midnight and 6:00 AM on 13 healthy preschool-aged children. P50 sensory gating, calculated during REM sleep, negatively correlated with spindle duration (r=-.715, p=.006) and inter-peak density (r=.744, p=.004). There was a trend toward higher S2/S1 ratios being associated with fewer peaks per spindle (r=-.546, p=.053). In 4-year-olds, 2 established physiological measures of sensory gating and are correlated despite being maximally active during different stages of sleep. CONCLUSIONS: These results suggest there is an overlap in brain mechanisms underlying each gating mechanism.
Source: PubMed
DOI: 10.25677/10968/4322
Institutions: Children's Hospital Colorado, University of Colorado Anschutz
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Basic to Clinical Molecular Neurobiology of Nicotinic Receptors in Schizophrenia, Colorado Clinical and Translational Science Institute (UL1), Attention and Smooth Pursuit in Infants with a Family History of Psychosis, Training Medical Students to Become Child Psychiatrists, Childhood Physiology and Risk for Schizophrenia, Colorado Clinical and Translational Science Institute (UL1)
OpenAlex ID: W3155008170