Elucidating Memory Specificity by Exploring Parvalbumin Interneuron Modulation of Perineuronal Nets
Year: 2020
Type: dissertation
Abstract: Infantile generalization, a unique type of generalization seen during early development, has not been widely studied in the ontogeny of memory. However, understanding this phenomenon is important for elucidating the mechanisms underlying the emergence of memory specificity. Preliminary studies form our lab have identified the ability of hippocampal perineuronal nets (PNNs) to bidirectionally modulate memory specificity. Other recent studies have determined that parvalbumin (PV) interneuron activity could modulate PNN assemblies in the visual cortex. Taken together, we predicted that PNN formations could be bidirectionally modulated by hippocampal CA1 PV interneuron activity, and in turn affect the emergence of memory specificity. Instead, only chemogenetic excitation of PV interneurons increased PNN intensities, while PV inhibition had no affect on PNN assemblies. It remains inconclusive whether these molecular changes impact the emergence of memory specificity, as only memory specificity was exhibited from both PV manipulations.
Source: TSpace (University of Toronto)
Author: Bi-ru Amy Yeung
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3155158713