Year: 2021
Type: dissertation
Abstract: Mitochondria, colloquially known as “the powerhouse of the cell”, play important roles not only energy production, but also in processes critical for cellular fate such as cell death, differentiation, signaling, metabolic homeostasis, and innate immunity. Due to their many functions in the cell, mitochondria have been linked to a variety of human illnesses such as diabetes, cancer, and neurodegenerative diseases. The target protein for this work was SIRT1, known to be involved in mitochondrial biogenesis. A mitochondrial targeted peptide was attached to known SIRT1 activators SRT1720 and SRT1460 in an attempt to increase mitochondrial biogenesis. Small improvements to mitochondrial health markers were seen upon treatment of these conjugated sirtuin activators, but more work is needed to confirm their efficacy.
Source: TSpace (University of Toronto)
Author: Cindy Ma
Language: English
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3155476971