The Role of BMAL1 in Linking the Molecular Clock and Circadian Rhythm of Cerebral Myogenic Tone
Year: 2021
Type: dissertation
Abstract: Cerebral arteries show a circadian rhythm in myogenic reactivity, the intrinsic ability of resistance arteries to adapt their tone to fluctuations in transmural pressure. The expression of cystic fibrosis transmembrane conductance regulator (CFTR), a known negative regulator of myogenic signalling in cerebral artery vascular smooth muscle cells (VSMCs), demonstrates cyclic behaviour in phase with other known circadian genes. I demonstrate that the known peak and trough of the CFTR protein expression rhythm are disrupted by abolishment of the peripheral molecular clock, induced by smooth muscle-specific deletion of Bmal1. A disruption to CFTR oscillations directly induced by peripheral clock dysfunction strengthens the hypothesis that CFTR is the site of circadian regulation of cerebral myogenic reactivity.
Source: TSpace (University of Toronto)
Author: Eily Alexandra Sinclair Shaw
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3155557568