Comprehensive and Computable Molecular Diagnostic Panel (C2Dx) From Small Volume Specimens for Precision Oncology: Molecular Subtyping of Non-Small Cell Lung Cancer From Fine Needle Aspirates
Year: 2021
Type: article
Abstract: (C2Dx) is a promising solution to address the need for a molecular pathological research and diagnostic tool for precision oncology utilizing small volume tumor specimens. We translate subtyping-related gene expression patterns of Non-Small Cell Lung Cancer (NSCLC) derived from public transcriptomic data which establish a highly robust and accurate subtyping system. The C2Dx demonstrates supreme performance on the NanoString platform using microgram-level FNA samples and has excellent portability to frozen tissues and RNA-Seq transcriptomic data. This workflow shows great potential for research and the clinical practice of cancer molecular diagnosis.
Source: Frontiers in Oncology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Funders: National Science Foundation, Wake Forest University, University of Texas at Austin, National Institutes of Health, Department of Mechanical Engineering, University of Texas at Austin, National Cancer Institute, Wake Forest Clinical and Translational Science Institute, Wake Forest School of Medicine
Awards: G1351188136, G171052541, G1742171491, Wake Forest Clinical and Translational Science Award, G2206590661, G3226045097, XSEDE 2.0: Integrating, Enabling and Enhancing National Cyberinfrastructure with Expanding Community Involvement, G4807429363, G4823677270, G7400298905, G9000271914, Cancer Center Support Grant
OpenAlex ID: W3155600247