Pulmonary Arterial Hypertension: Diagnosis, Treatment, and Novel Advances
Year: 2021
Type: article
Abstract: The diagnosis and management of pulmonary arterial hypertension (PAH) includes several advances, such as a broader recognition of extrapulmonary vascular organ system involvement, validated point-of-care clinical assessment tools, and focus on the early initiation of multiple pharmacotherapeutics in appropriate patients. Indeed, a principal goal in PAH today is an early diagnosis for prompt initiation of treatment to achieve a minimal symptom burden; optimize the patient's biochemical, hemodynamic, and functional profile; and limit adverse events. To accomplish this end, clinicians must be familiar with novel risk factors and the revised hemodynamic definition for PAH. Fresh insights into the role of developmental biology (i.e., perinatal health) may also be useful for predicting incident PAH in early adulthood. Emergent or underused approaches to PAH management include a novel TGF-β ligand trap pharmacotherapy, remote pulmonary arterial pressure monitoring, next-generation imaging using inert gas-based magnetic resonance and other technologies, right atrial pacing, and pulmonary arterial denervation. These and other PAH state of the art advances are summarized here for the wider pulmonary medicine community.
Institutions: Brigham and Women's Hospital, Harvard University, Children's Hospital Colorado, University of Colorado Anschutz, University of Utah, Intermountain Medical Center, Mayo Clinic, Stanford Medicine, Stanford University, Cornell University, Weill Cornell Medicine, VA Palo Alto Health Care System, Inova Fairfax Hospital, Northwestern University, Medical University of Graz, Ludwig Boltzmann Institute for Lung Vascular Research, Columbia University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Transition from Risk Factors to Early HF: Prevalence, Pathogenesis, and Phenomics, Role of VEGF in Perinatal Hypertension, Critical Role for Microvasculature in Airway Transplantation, Precision Medicine for Dilated Cardiomyopathy—Novel Assessment of Cardiac Mechanics via Speckle Tracking Echocardiography to Identify Early Phenotypes, G3497624121, G4315613590, Personalized protein-protein interactomes and precision medicine in pulmonary arterial hypertension, Boston Biomedical Innovation Center, A Critical Role for Leukotriene B4 in Lymphedema, Fibrosome regulation by aldosterone in pulmonary vascular disease, Machine learning for the automated identification and tracking of rare myocardial diseases, Physiological Phenotyping of Respiratory Outcomes in Infants Born Premature, Integrative Omics as a Discovery Tool for Pulmonary Hypertension, Adaptation to Hypoxia, Network medicine, risk stratification, and pulmonary hypertension, Determinants, Trajectories, and Consequences of Abnormal Cardiac Mechanics, NEDD9-SMAD3, fibrinolysis, and chronic thromboembolic pulmonary hypertension, Targeting FAK-NEDD9 protein-protein interaction to prevent focal adhesion assembly and vascular proliferation in pulmonary arterial hypertension, BMPR2, Monocytes and Macrophages in Pulmonary Artery Hypertension, Regulatory T Cells and Pulmonary Hypertension
OpenAlex ID: W3155667389