Impact of Bariatric Surgery on Circulating Inflammatory and Pro-vascular Progenitor Cell Populations
Year: 2020
Type: dissertation
Abstract: Obesity is a growing healthcare concern with more than 2 billion adults worldwide affected by unhealthy weight gain. Since bariatric surgery can induce significant cardiometabolic improvements and reduce adverse cardiovascular events, we hypothesized that these benefits may occur through decreased circulating inflammatory cell burden and increased pro-vascular progenitor cell content. High aldehyde dehydrogenase- (ALDH) activity and cell surface markers were assessed by flow cytometry for circulating progenitor cell content, M1/M2 macrophage balance, and pro-inflammatory cell burden between normal weight controls and individuals before and after bariatric surgery. At 3 months, ALDHhiSSChi granulocytes were reduced 2-fold and ALDHhiSSCmid monocyte/macrophage precursors were increased 2-fold, to frequencies equivalent to normal weight controls. Pro-angiogenic ALDHhiSSClow cells with primitive CD34+/CD133+ co-expression were enriched following surgery. Collectively, these data suggest that bariatric surgery induced beneficial changes in circulating progenitor cell content, consistent with improved vascular regenerative capacity and lower cardiovascular risk.
Source: TSpace (University of Toronto)
Author: Justin Z. Trac
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3155883187