Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety
Work
Year: 2021
Type: article
Abstract: The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (hDHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from pharma as a possible AML... more
Source: Journal of Medicinal Chemistry
Institutions University of Turin, Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Mario Negri Institute for Pharmacological Research, Candiolo Cancer Institute, South China University of Technology +3 more
Cites: 61
Cited by: 25
Related to: 10
FWCI: 1.789
Citation percentile (by year/subfield): 100
Subfield: Molecular Biology
Domain: Life Sciences
Sustainable Development Goal Good health and well-being
Open Access status: hybrid