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Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

Year: 2018

Type: article

Abstract: Mendelian randomisation uses genetic variation as a natural experiment to investigate the causal relations between potentially modifiable risk factors and health outcomes in observational data. As with all epidemiological approaches, findings from Mendelian randomisation studies depend on specific assumptions. We provide explanations of the information typically reported in Mendelian randomisation studies that can be used to assess the plausibility of these assumptions and guidance on how to interpret findings from Mendelian randomisation studies in the context of other sources of evidence

Source: BMJ

DOI: 10.1136/bmj.k601

Authors: Neil M Davies, Michael V Holmes, George Davey Smith

Institutions: University of Bristol, MRC Integrative Epidemiology Unit, National Institute for Health and Care Research, University of Oxford, NIHR Oxford Biomedical Research Centre, MRC Population Health Research Unit, NIHR Bristol Biomedical Research Centre

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: British Heart Foundation, Imperial College London, University of Oxford, University of Bristol, Erasmus Universiteit Rotterdam, Economic and Social Research Council

Awards: Informing educational interventions using genome-wide data: causal evidence from 573,586 participants of eight cohort studies, Drug target validation and risk prediction for coronary heart disease using targeted blood-based metabolomics and proteomics

OpenAlex ID: W2818417770

FWCI: 79.28

Cites: 94

Cited by: 4,399

Related to: 10