Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study
Year: 2021
Type: article
Study design: Observational Study
Abstract: Duration of untreated psychosis (DUP) is associated with clinical outcomes in people with a diagnosis of first-episode psychosis (FEP), but factors associated with length of DUP are still poorly understood. Aiming to obtain insights into the possible biological impact on DUP, we report genetic analyses of a large multi-center phenotypically well-defined sample encompassing individuals with a diagnosis of FEP recruited from 6 countries spanning 17 research sites, as part of the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study. Genetic propensity was measured using polygenic scores for schizophrenia (SZ-PGS), bipolar disorder (BD-PGS), major depressive disorder (MDD-PGS), and intelligence (IQ-PGS), which were calculated based on the results from the most recent genome-wide association meta-analyses. Following imputation for missing data and log transformation of DUP to handle skewedness, the association between DUP and polygenic scores (PGS), adjusting for important confounders, was investigated with multivariable linear regression models. The sample comprised 619 individuals with a diagnosis of FEP disorders with a median age at first contact of 29.0 years (interquartile range [IQR] = 22.0-38.0). The median length of DUP in the sample was 10.1 weeks (IQR = 3.8-30.8). One SD increases in SZ-PGS, BD-PGS, MDD-PGS or IQ-PGS were not significantly associated with the length of DUP. Our results suggest that genetic variation does not contribute to the DUP in patients with a diagnosis of FEP disorders.
Source: Schizophrenia Bulletin
Authors: Olesya Ajnakina, Victoria Rodriguez, Diego Quattrone, Marta di Forti, Evangelos Vassos, Celso Arango, Domenico Berardi, Miguel Bernardo, Julio Bobes, Lieuwe de Haan, Cristina Marta Del-Ben, Charlotte Gayer-Anderson, Hannah E Jongsma, Antonio Lasalvia, Sarah Tosato, Pierre-Michel Llorca, Paulo Rossi Menezes, Bart P Rutten, Jose Luis Santos, Julio Sanjuán, Jean-Paul Selten, Andrei Szöke, Ilaria Tarricone, Giuseppe D’Andrea, Alexander Richards, Andrea Tortelli, Eva Velthorst, Peter B Jones, Manuel Arrojo Romero, Caterina La Cascia, James B Kirkbride, Jim van Os, Mick O’Donovan, Robin M Murray, EU-GEI WP2 Group
Institutions: University of London, King's College London, Aarhus University, University College London, Universidad Complutense de Madrid, Hospital General Universitario Gregorio Marañón, University of Bologna, Centro de Investigación Biomédica en Red de Salud Mental, Hospital Clínic de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Amsterdam University Medical Centers, University of Amsterdam, Universidade de São Paulo, University Medical Center Groningen, University of Verona, Centre National de la Recherche Scientifique, Institut Pascal, Université Clermont Auvergne, Clermont Auvergne INP, Maastricht University Medical Centre, Hospital Virgen de la Luz, Universitat de València, Hospital Clínico Universitario de Valencia, GGZ Rivierduinen, Inserm, Université Paris-Est Créteil, Fondation FondaMental, Assistance Publique – Hôpitaux de Paris, Institut Mondor de Recherche Biomédicale, Cardiff University, Amsterdam UMC Location University of Amsterdam, Icahn School of Medicine at Mount Sinai, University of Cambridge, Cambridgeshire and Peterborough NHS Foundation Trust, Complejo Hospitalario Universitario de Santiago, Instituto de Investigación Sanitaria de Santiago, University of Palermo, Utrecht University, University Medical Center Utrecht, Maastricht University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,280
Funders: NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research, National Institute for Health and Care Research, Leverhulme Trust, Department of Health and Social Care, Guarantors of Brain, University College London, Fundação de Amparo à Pesquisa do Estado de São Paulo, Casen Recordati, H. Lundbeck A/S, Medical Research Council, Cilag
OpenAlex ID: W3157082332