Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia
Year: 2021
Type: article
Source: Nature Neuroscience
Institution: University of California, Los Angeles
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Health and Human Services, Simons Foundation, Yale University, University of Southern California, State University of New York, Johns Hopkins University, National Institutes of Health, University of California, Los Angeles, University of California, San Francisco, State University of New York Upstate Medical University, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Human Genome Research Institute, NIH Office of the Director, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Common Fund
Awards: Integrative Genomics of the Corticolimbic Circuit in Major Depressive Disorder, G1512019062, 1/3 Integrative Genomic Analysis of Human Brain Development and Autism, 1/2 Discovery and validation of neuronal enhancers associated with the development of psychiatric disorders, G2179511623, Transcriptional and Epigenetic Signatures of Human Brain Development and Autism, G2730019790, G3021430819, 2/2 Discovery and validation of neuronal enhancers associated with the development of psychiatric disorders, G3292107581, Long non-coding RNAs in gene regulatory networks underlying Autism, Decomposing cell type-specific marks in post-mortem human brain studies, 1/2 Measuring translational dynamics and the proteome to identify potential brain biomakers for psychiatric disease, Isoform-level probabilistic transcriptome-wide association to undercover neurogenetic mechanisms underlying complex psychiatric traits, G3755105752, Gene regulatory elements and transcriptome in iPSCs and embryonic human cortex, 2/3 Integrative Genomic Analysis of Human Brain Development and Autism, Risk genetic variants and cis regulation of gene expression in Bipolar Disorder, UCLA IDDRC, 3/3 Chromatin regulation during brain development and in ASD, 2/3 Chromatin regulation during brain development and in ASD, UCLA-Caltech Medical Scientist Training Program, G5520058391, Genetic variants affect brain gene expression and risks of psychiatric disorders, Establishing comprehensive and quantitative maps of DNA methylation in the develo, G5892662811, G589664268, 1/3 Chromatin regulation during brain development and in ASD, G6242744535, Dynamic RNA Modifications in human brain development and autism, Functional Genomics of Human Brain Development, 2/2 - Cell Type and Region-Specific Regulatory Networks in Human Brain Development and Disorders, 2/2-Measuring translational dynamics and the proteome to identify potential brain biomarkers for psychiatric disease, Cis-Regulatory Epigenome Mappings in Schizophrenia, RNA Sequencing of the Limbic System in Bipolar Disorder, The 3D genome in transcriptional regulation across the postnatal life span, with implications for schizophrenia and bipolar disorder, GABA Epigenomes in Autism, Epigenetic and Transcriptional Dysregulation in Autism Spectrum Disorder, Mapping the role of long noncoding RNAs in gene regulatory networks in schizophrenia, Training Grant in Neurobehavioral Genetics, G7591477523, Characterizing the developing human brain transcriptome at single-base resolution, Population-level and mechanistic dissection of 17q21 structural variant association with psychiatric traits, The USC PsychENCODE Project, G7981566897, G8034151469, 3/3 Integrative Genomic Analysis of Human Brain Development and Autism, Massively parallel characterization of psychiatric disease associated regulatory elements in defined cell types, G8411673328, Molecular Profiling of Schizophrenia, Gene-brain-environment interactions as determinants of typical and atypical developmental trajectories, 1/2 Cell Type and Region-Specific Regulatory Networks in Human Brain Development and Disorders, Cellular and developmental genetic regulation of 3' isoform diversity in the human brain and its contribution to neuropsychiatric disorders, 1/3 Understanding PTSD through Postmortem Targeted Brain Multi-omics, Site 3/3, Understanding PTSD through Postmortem Targeted Brain Multiomics, Training Grant in Neurobehavioral Genetics, 2/3 Understanding PTSD through Postmortem Targeted Brain Multi-omics, Neurodevelopment and Psychosis in the 22q11.2 Copy Number Variants
OpenAlex ID: W3157247664