Work

Analysis of key genes and related transcription factors in liver fibrosis based on bioinformatic technology.

Year: 2021

Type: article

Abstract: OBJECTIVE: To analyze differentially expressed genes (DEGs) related to liver fibrosis, and clarify the key genes and the possible targets in the progression of liver fibrosis. METHODS: Using microarray datasets, GSE38199 was extracted from Gene Expression Omnibus (GEO), and a bioinformatics method was performed to find DEGs and transcription factors related to liver fibrosis. RESULTS: ) were screened out. A total of 30 transcription factors were found according to these 9 key genes, of which 4 transcription factors (Stat3, Trp53, NF-κB1, Sp1) were enriched. CONCLUSION: might be a target for liver fibrosis.

Source: PubMed

Authors: Xue Yang, Qi-Ni Cheng, Jiang-Feng Wu, Wen-Bing Ai, Lan Ma

Institutions: China Three Gorges University, Yancheng Second People's Hospital, Yixing Tumor Hospital

Language: English

Topic: Liver physiology and pathology

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3157460230

FWCI: 0.352

Cites: 43

Cited by: 5

Related to: 10