Decursin inhibits cell growth and autophagic flux in gastric cancer via suppression of cathepsin C.
Year: 2021
Type: article
Abstract: . We established spheroid and patient-derived organoid models and found that decursin decreased the growth of spheroids and patient-derived gastric organoids, as well as modulated the expression of CTSC and autophagy-related proteins. Hence, our findings uncovered a previously unknown mechanism by which decursin regulates cell growth and autophagy and suggests that decursin may act as a potential therapeutic agent that simultaneously inhibits cell growth and autophagy.
Source: PubMed
Authors: Solbi Kim, Sang-Il Lee, Nayoung Kim, Mina Joo, Kyung-Ha Lee, Myung-Won Lee, Heung Jin Jeon, Hyewon Ryu, Jin-Man Kim, Ji-Young Sul, Gyu-Yong Song, Ji-Yeon Kim, Hyo Jin Lee
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3157653718