Work

Breakthrough of interspecific chimerism: blocking apoptosis

Year: 2021

Type: article

Abstract: On January 28 in Nature online, Zheng et al. (Nature, 2021 (Online ahead of print)) reported that they developed an ingenious method of interspecies PSC co-culture system in vitro which unfolded interspecific cell competition. This study paves the way for discovering the mechanism of interspecific chimera and for further interspecific organogenesis between evolutionarily distant species.

Source: Cell Regeneration

DOI: 10.1186/s13619-021-00080-w

Authors: Yiren Qin, Duancheng Wen

Institution: Weill Cornell Medicine

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: Direct generation of complex genetically-modified mouse models via embryonic stem cells, H3.3-mediated epigenetic regulation of developmental bivalent genes for reprogramming and differentiation